منابع مشابه
Decreased nitric oxide synthesis in rats with chronic renal failure.
The present study was aimed at investigating whether an altered role of nitric oxide (NO) is involved in chronic renal failure (CRF). Rats were subjected to 5/6 nephrectomy and kept for 6 weeks to induce CRF. On the experimental day, after measurement of arterial pressure under anesthesia, the arterial blood was collected, and thoracic aorta and kidney were rapidly taken. NO metabolites (NOx) w...
متن کاملNitric oxide, oxidative stress, and progression of chronic renal failure.
Cellular injury or organ dysfunction from oxidative stress occurs when reactive oxygen species (ROS) accumulate in excess of the host defense mechanisms. The deleterious effect of ROS occurs from 2 principal actions. First, ROS can inactivate mitochondrial enzymes, damage DNA, or lead to apoptosis or cellular hypertrophy. Second, nitric oxide (NO), which is a principal endothelial-derived relax...
متن کاملAbnormalities in L-arginine transport and nitric oxide biosynthesis in chronic renal and heart failure.
Patients with chronic renal and heart failure present with hypertension and widespread vasoconstriction, respectively. Although systemic release of nitric oxide (NO) may be elevated in both pathological syndromes, enhanced production of NO fails to overcome endothelial dysfunction. Plasma concentrations of L-arginine, a cationic amino acid precursor for NO synthesis, are reduced whilst levels o...
متن کاملNitric oxide production is reduced in patients with chronic renal failure.
In patients with chronic renal failure (CRF), atherosclerosis is a major cause of cardiovascular morbidity and mortality. Generally, atherosclerosis has been associated with a reduced bioavailability of nitric oxide (NO). Experimental studies have indicated the presence of enhanced NO degradation by reactive oxygen species as well as decreased NO production as possible causes for this reduced N...
متن کاملOxidative stress, serum homocysteine and serum nitric oxide in different stages of chronic renal failure
Chronic renal failure is accompanied by oxidative stress, which is caused by reactive oxygen species and impaired antioxidant defense. In this study we investigated oxidative stress in chronic renal failure patients. In the present study, 150 CRF patients and 50 healthy controls matching age and sex were included. We have estimated serum lipid peroxidation, serum superoxide dismutase, serum nit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kidney International
سال: 2005
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2005.00259.x